In 1910 Flexner1 attempted the immunization of a horse to poliomyelitis virus but without success, as evidenced by negative neutralization tests. In 1917 Neustaedter and Banzhaf2 inoculated a horse with the trypsinized virus. The results, however, were unsatisfactory. They later repeated the inoculations but gave large doses of brain and cord suspensions subcutaneously instead of the previous material. The serum obtained neutralized the virus in several trial tests but gave only doubtful results when tried therapeutically in human cases of poliomyelitis. More recently (1929), Weyer, Park and Banzhaf3 have reported on the production of a more potent antiviral horse serum, which they have also been attempting to purify by precipitation methods.
Pettit,4 in 1918, reported the successful immunization of a sheep to poliomyelitis virus, extending his methods later to a horse. Both these animal serums have been extensively used by European physicians for human cases, some
HOWITT BF, SHAW EB, THELANDER H, LIMPER M. THE IMMUNIZATION OF GOATS AND SHEEP TO POLIOMYELITIS VIRUS: CLINICAL APPLICATION OF THEIR SERUMS. JAMA. 1931;96(16):1280–1284. doi:10.1001/jama.1931.02720420004002
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