The effect of loss of blood in donors has not received the careful attention that the subject warrants. Most of the studies1 have been limited to notations concerning health, the necessity of repeated Wassermann tests and the careful matching of blood. It is reported that in one institution a student is permitted to donate blood only once in a semester. This rule was made because one of the students fell seriously ill following a blood donation. McNamara2 has stated that he does not make routine Wassermann tests on his donors, as most of those available had syphilis and in his experience the disease was not transmitted if present in the tertiary stage. Giffin and Haines,3 from a study of donors made at indefinite intervals after blood donation, concluded that bloodletting every four or five weeks was not harmful; that Women developed anemia more rapidly and recovered more
JONES HW, WIDING H, NELSON L. BLOOD DONORS: A STUDY OF THE EFFECT IN DONORS OF REPEATED BLOOD LOSS. JAMA. 1931;96(16):1297–1300. doi:10.1001/jama.1931.02720420021008
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