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April 25, 1931

ADDISON-BIERMER'S ANEMIA (PERNICIOUS ANEMIA)REPORT OF CASE SHOWING ALLERGIC-LIKE PHENOMENA TO LIVER EXTRACT

JAMA. 1931;96(17):1361-1363. doi:10.1001/jama.1931.02720430011003

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Abstract

Our reason for reporting this case is the fact that although the patient reacted to liver extract with phenomena hitherto not observed so far as we can determine, he reacted favorably to beef-cooked liver. An explanation that seems plausible is offered for these phenomena.

Before presenting the case we wish to repeat1 that it seems to us that the name "pernicious anemia" is today not a justifiable one for the disease to which it refers. The liver treatment of Minot and Murphy in this condition is so efficacious and produces such absolute relief of the object symptoms and improvement of the hematologic manifestations that "pernicious" is no longer descriptive. We feel that the name "Addison-Biermer's anemia," in recognition of the English and German clinicians, respectively, who so vividly and accurately described the clinical picture of this disease, is very appropriate. Schilling,2 feeling likewise that the name pernicious anemia

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