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Article
February 25, 1928

SEPARATION OF THE ACTIVE PRINCIPLES OF THE POSTERIOR LOBE OF THE PITUITARY GLAND

JAMA. 1928;90(8):618-619. doi:10.1001/jama.1928.02690350036015
Abstract

Like the pancreas and the suprarenal glands, the pituitary contains two portions that differ in function and in pharmacology. Sollmann1 has pointed out the remarkable fact that the parts of the suprarenal and pitiutary which are the most important to life have the least pharmacologic actions, while the parts whose extracts produce exceedingly striking pharmalogic effects—the suprarenal medulla and the posterior pituitary—appear to be of minor importance to the organism. Equally remarkable are the manifold activities of the extract of that portion of the pituitary gland which is not so important to life, as exemplified in the official solution of pituitary (posterior pituitary lobe); its effect in stimulating uterine contractions (oxytocic activity), its ability to raise blood pressure (pressor activity) and its marked diuretic-antidiuretic effects (renal activity) are well known. The chief clinical applications of these effects are in themselves likewise widely variant; the use of pituitary solutions to

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