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To the Editor The CHECKLIST-ICU investigators assessed the effect of a quality improvement intervention on the mortality of adults who were critically ill using a cluster randomized trial.1 The results were not significant. However, we believe that the results should be interpreted with caution because cluster randomized trials can be susceptible to a range of methodological problems.
Nunez RM, Perdomo HAG, Chavez ICM. Quality Improvement Intervention and Mortality of Critically Ill Patients. JAMA. 2016;316(8):879. doi:10.1001/jama.2016.9269
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