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In Reply We agree with Dr Anghelescu that it is remarkable that a major depressive episode can be prevented in people with subthreshold depression with a brief 6-session intervention. However, although this study was the first one showing that it is possible to prevent a major depressive episode using a web-based guided self-help intervention, evidence is accumulating that this can be achieved with brief face-to-face interventions.1
Ebert DD, Buntrock C, Cuijpers P. Online Intervention for Prevention of Major Depression—Reply. JAMA. 2016;316(8):881–882. doi:10.1001/jama.2016.9586
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