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November 10, 1934


JAMA. 1934;103(19):1420-1421. doi:10.1001/jama.1934.02750450004002

Discussions have arisen from time to time concerning the addiction liability of codeine and its value as a therapeutic agent for the relief of those withdrawal phenomena seen when morphine is abruptly withheld from persons addicted to its use. Although generally conceded to be nonaddicting, various authors, notably Sollier,1 Petty,2 Lambert,3 White,4 Rouges de Fursac and Monestier,5 Terry6 and Sollmann,7 have indicated that codeine possesses this propensity. It was therefore considered advisable to investigate the addiction liability of codeine before employing it in the treatment of abrupt morphine deprivation. The studies with which this article deals, however, attempt to record certain preliminary observations necessary for carrying out a cooperative investigation sponsored by the Committee on Drug Addiction of the Medical Science Division of the National Research Council.

The Committee on Drug Addiction of that council, supported by funds from the Rockefeller Foundation, in