Acute yellow atrophy of the liver, also known as icterus gravis, acute parenchymatous hepatitis, malignant jaundice, parenchymatous degeneration of the liver or acute necrosis of the liver, is a widespread degeneration of the liver with toxic manifestations, jaundice and a reduction in the size of the liver. We prefer the term acute necrosis as more descriptive of the condition but will adhere to acute yellow atrophy, as it is so well established in the literature. It is known to occur at all ages in both sexes but is rare in pregnancy. The first case of acute yellow atrophy of the liver in pregnancy was described by Kerkring in 1706 and quoted by Williams,1 and most writers since then have referred to the relation of the disease to pregnancy. Although very rare, it may be epidemic, as reported by Kent,2 who observed 14 cases within eighteen months, all in
WHITACRE FE, FANG LY. FATTY DEGENERATION OF THE LIVER IN PREGNANCY: REPORT OF A CASE WITH RECOVERY: CHEMICAL AND HISTOLOGIC STUDIES. JAMA. 1942;118(16):1358–1364. doi:10.1001/jama.1942.02830160018005
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