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JAMA Clinical Evidence Synopsis
September 13, 2016

Colchicine and Prevention of Cardiovascular Events

Author Affiliations
  • 1Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
  • 2Department of Clinical Research, University of Basel, Basel, Switzerland
  • 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
JAMA. 2016;316(10):1106-1107. doi:10.1001/jama.2016.11044

Clinical Question  Is continuous long-term treatment with colchicine associated with lower rates of all-cause mortality and myocardial infarction and higher rates of adverse events?

Bottom Line  Continuous long-term treatment with colchicine may be associated with lower rates of myocardial infarction, but may be associated with higher rates of gastrointestinal adverse events.