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Comment & Response
September 13, 2016

Sodium Excretion, Cardiovascular Disease, and Chronic Kidney Disease

Author Affiliations
  • 1Department of Internal Medicine, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey
JAMA. 2016;316(10):1112. doi:10.1001/jama.2016.11550

To the Editor In the study by Mills and colleagues,1 high urinary sodium excretion was associated with increased cardiovascular disease (CVD) risk in patients with chronic kidney disease (CKD). Patients were divided into 4 groups based on quartiles of calibrated urinary sodium excretion (<2894 mg/24 hours; 2894-3649 mg/24 hours; 3650-4547 mg/24 hours; and ≥4548 mg/24 hours) and were followed up for a median of 6.8 years. The cumulative incidence of CVD for each group from lowest to highest urinary sodium excretion was 18.4%, 16.5%, 20.6%, and 29.8%, respectively. After multivariable adjustment, no significant association was found between urinary potassium excretion and CVD events.