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To the Editor Timing of initiation of renal replacement therapy (RRT) in patients with severe acute kidney injury (AKI) remains controversial. Several well-designed, randomized clinical trials have been published or are ongoing.1-4 The single-center Early vs Late Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury (ELAIN) trial found an early strategy of initiating RRT compared with a delayed strategy reduced mortality in patients who were critically ill.1
Wang H, Li C, Hou X. Timing of Initiation of Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury. JAMA. 2016;316(11):1212–1213. doi:10.1001/jama.2016.11320
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