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Article
December 1, 1934

THE OCCURRENCE AND TREATMENT OF NEUROLOGIC CHANGES IN PERNICIOUS ANEMIA

JAMA. 1934;103(22):1663-1667. doi:10.1001/jama.1934.02750480001001
Abstract

In recent years with the advent of a potent medication for the treatment of the anemia of pernicious anemia, a great deal of consideration has been given to the effect of liver and desiccated stomach therapy on the associated lesions of the spinal cord and brain in this disease. Innumerable workers have reported, with considerable diversity of opinion,1 the results of their investigation concerning the progression and prevention of nervous system involvement. Our purpose in this paper is to present a study of a comparatively large group of patients, extending over a period of seven years, concerning the occurrence of neurologic and mental manifestations in pernicious anemia and to determine the effect of various types of antianemic therapy on them.

The group consisted of 461 patients with pernicious anemia observed at the Simpson Memorial Institute between the years 1927 and 1934. Comprising this group were 261 men (56.6 per

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