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Article
December 8, 1934

BACTERIOPHAGE THERAPY: REVIEW OF THE PRINCIPLES AND RESULTS OF THE USE OF BACTERIOPHAGE IN THE TREATMENT OF INFECTIONS

Author Affiliations

NEW HAVEN, CONN.
From the Department of Bacteriology, Yale University School of Medicine.

JAMA. 1934;103(23):1769-1776. doi:10.1001/jama.1934.72750490003007
Abstract

The purpose of this report is (a) to present summaries and discussions of (1) the experimentally determined facts relating to the bacteriophage phenomenon, (2) the laboratory and clinical evidence for and against the therapeutic usefulness of bacteriophage and (3) the relation of so-called antivirus to materials containing bacteriophage, and (b) to serve as a basis for a survey of the status of some of the commercial preparations. As it is impossible to include in this article an abstract of the whole voluminous and contradictory literature on these subjects, we have summarized only the papers and reviews that have appeared to us to be the most significant.

MODE OF ACTION AND NATURE OF BACTERIOPHAGE  Transmissible lysis of bacteria was discovered independently by Twort1 in 1915 and by d'Herelle2 in 1917. As d'Herelle has stated that he noticed the effect of the lytic agent first in 1909 and as the

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