To the Editor Kor and colleagues1 hypothesized that aspirin would prevent acute respiratory distress syndrome (ARDS) in high-risk patients due to its anti-inflammatory and antiplatelet effects. The trial failed to demonstrate any beneficial effect of aspirin administered to patients presenting to the emergency department on the subsequent development of ARDS during their hospital stay. The authors stated that the aspirin dosage (1 loading dose of 325 mg on day 1, followed by 81 mg once daily up to hospital day 7, discharge, or death) was selected based on results of 2 published studies.
Robert A. Kuschner. Aspirin and Acute Respiratory Distress Syndrome. JAMA. 2016;316(12):1317–1318. doi:10.1001/jama.2016.12322