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May 9, 1931


JAMA. 1931;96(19):1573-1574. doi:10.1001/jama.1931.27220450002007a

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As a general rule, benign epithelial tumors do not metastasize. Primary adenomas of the thyroid gland do, however, occasionally metastasize, especially to the bones or to the lungs. A limited number of such cases are on record. Indeed, such metastases of thyroid tissue, which may be either benign or malignant in character, have been reported in cases that showed no clinical evidence of thyroid hyperplasia. American literature on this subject is sparse, and I therefore report a case:

Miss E. D., aged 33, white, entered the American Hospital, Aug. 30, 1930, for treatment of a growth in the neck. Her family history was irrelevant; some antecedents pointed to heart trouble and tuberculosis.

In 1912, shortly after the onset of menstruation, at about the age of 15, the patient first noticed that her neck was swollen. The condition became progressively worse and she entered a hospital in New York, where she

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