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June 6, 1942

Clinical and Experimental Histological Studies on Effects of Salicylate and Quinine on the Ear

JAMA. 1942;119(6):533. doi:10.1001/jama.1942.02830230067036

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The war apparently has not been able, even in Europe, to smother entirely the type of detailed clinical study represented by this monograph, which evidences a great deal of work and is in the true continental style with full preliminary remarks on the pharmacology of the drugs investigated, namely salicylic acid and quinine; and it includes an extensive critical survey of all available pertinent preexisting contributions on the subject of the author's studies. He then relates the manner in which he tested hearing and labyrinthine functions in order to establish normal criteria. Under proper controls both tuning forks and the audiometer were used; healthy volunteers were examined after ingestion of sodium salicylate and quinine sulfate; patients with abnormal hearing were similarly tested and there were a number of instances in which individuals with acute quinine poisoning and protracted salicylate ingestion were observed. There were, in addition, controlled animal experiments with

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