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Article
December 22, 1934

BACTERIOPHAGE THERAPY: REVIEW OF THE PRINCIPLES AND RESULTS OF THE USE OF BACTERIOPHAGE IN THE TREATMENT OF INFECTIONS

Author Affiliations

NEW HAVEN, CONN.

JAMA. 1934;103(25):1934-1939. doi:10.1001/jama.1934.72750510005009
Abstract

Bacteriophage in the Treatment of Plague.—  d'Herelle,123 reported successful results from the injection of a highly "virulent" bacteriophage into the buboes in four cases of bubonic plague. He stated that, as a result of bacteriologic examination of the buboes, lysis of the organisms in vivo had occurred. Pons124 and Couvy,125 as a result of more detailed studies, have also come to the conclusion that lysis of the organisms in vivo occurs in cases of plague injected with bacteriophage. Couvy126 treated twenty-one cases of plague with bacteriophage and observed a mortality of 33 per cent. In 124 serum treated cases the mortality was 65.3 per cent. In a following year this author further studied 245 cases of plague. Seventy-two of these patients died within less than twenty-four hours after admission to the hospital and were not treated with bacteriophage. In the remaining 173 cases treated with bacteriophage

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