The chemical compound dioxyanthranol 1-8 differs in its structural formula from chrysarobin by the lack of the methyl group. It is formed by reduction from dioxyanthraquinone 1-8, a substance used in industry. Dioxyanthranol 1-8, under the trade name Cignolin, was introduced into dermatology in 1916 as a substitute for chrysarobin by Galewsky1 and Unna.2 The latter carried through elaborate studies of its action on normal and diseased epidermis and showed that the elimination of the methyl group was responsible for the superior activity of the drug, that the 1-8 position of the hydroxyl groups in both chrysarobin and dioxyanthranol is responsible for the antisporiatic effect, and that the latter is approximately from two to five times as effective as the former on the same patient. Apparently, owing to manufacturing difficulties, it was withdrawn from the market in 1924 over the protest of Grumach3 and Hauck,4 but
BEERMAN H, KULCHAR GV, PILLSBURY DM, STOKES JH. DIOXYANTHRANOL 1-8 AS A SUBSTITUTE FOR CHRYSAROBIN. JAMA. 1935;104(1):26–29. doi:10.1001/jama.1935.02760010028005
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