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From The Medical Letter on Drugs and Therapeutics
October 4, 2016

Alternatives to Fluoroquinolones

JAMA. 2016;316(13):1404-1405. doi:10.1001/jama.2016.8383

The FDA has announced that it is requiring changes in the labeling of systemic fluoroquinolones to warn that the risk of serious adverse effects, including tendinitis, peripheral neuropathy and CNS effects, generally outweighs their benefit for the treatment of acute sinusitis, acute exacerbations of chronic bronchitis, and uncomplicated urinary tract infections. For these infections, the new labels will recommend reserving fluoroquinolones for patients with no other treatment options.1