From the work of William Mansfield Clark1 it has been shown that it is practically impossible to increase the acidity of the urine sufficiently by the oral administration of any drug to inhibit entirely the growth of the colon bacillus. Because of this it was decided to try the effect of altering the food intake. Barborka2 suggested that the ketogenic diet, which had been used originally by Wilder in the treatment of epilepsy, produced an acidity of the urine considerably above the normal. Previously, Johnson3 had placed several patients with a bacillary infection of the urinary tract on the ketogenic diet. He noted some improvement in their condition, but the patients were too ill to allow a thorough test of the treatment. About this time Helmholz had noted that the urine of a patient on the ketogenic diet for the treatment of epilepsy remained clear and apparently
CLARK AL, KELTZ BF. A SIMPLIFIED TREATMENT OF BACILLURIA. JAMA. 1935;104(4):289–292. doi:10.1001/jama.1935.02760040021005
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