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Article
February 2, 1935

Studies in Asphyxia:

JAMA. 1935;104(5):422-423. doi:10.1001/jama.1935.02760050068034

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Abstract

This bulletin of the Public Health Service presents in brief form a thorough study of the neuropathology resulting from (a) rapid, (b) slow and (c) long continued carbon monoxide asphyxia, (d) the comparable neuropathology of rapid asphyxia by atmospheres deficient in oxygen but containing no carbon monoxide, and the blood chemistry changes resulting from (e) rapid asphyxia by simple anoxia and (f) those induced by rapid carbon monoxide asphyxia. Photomicrographs of sections of the brains of asphyxiated dogs and rats are reproduced. Two types of degenerative changes were observed in nerve cells, some becoming shrunken and staining diffusely, others showing varying degrees of chromatolysis. In dogs these changes occurred chiefly in the cells of the cerebral cortex, in the corpus striatum and other basal ganglions. In rats the cortex was much less injured. In both species of animals, vascular changes were marked: dilatation of small blood vessels, stasis and perivascular

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