In 1924 a series of articles—published in book form the following year and revised in 1927—was prepared under the auspices of the Council on Pharmacy and Chemistry of the American Medical Association with the general title "Glandular Therapy." In a brief introduction to that series Dr. Frank Billings emphasized certain significant factors in relationship to our knowledge of the glands which at that time many endocrinologists considered as established but which to some physiologists and clinicians were not quite acceptable. The points to which he referred concerned the alleged reciprocal action of the glands of internal secretion; i. e., the idea that the glands represent an interlocking chain of structures correlated in their activities through hormones carried in the blood stream. This led to the view that the entire functioning of the body might be stimulated, retarded or perverted by hyperfunction, hypofunction or alleged dysfunction of the ductless glands. It
FISHBEIN M. INTRODUCTION. JAMA. 1935;104(6):463–464. doi:10.1001/jama.1935.92760060004008
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