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February 23, 1935


Author Affiliations


JAMA. 1935;104(8):605-609. doi:10.1001/jama.1935.02760080001001

Roentgen rays have been used in the treatment of malignant tumors for thirty-four years, but the general acceptance of technics delivering efficient dosages has been a very slow process. Pusey1 reported cases of proved carcinoma of the lip treated successfully with many times an erythema dose twenty-seven years ago, but most dermatologists are still unwilling to use such effective therapy through fear of injury to normal tissues. Experienced radiologists discovered long ago that the actual cure of carcinoma requires the administration of from 5 to 10 erythema doses of x-rays, and even more in some instances. However, the first well presented proof of this fact was brought forward by Martin and Quimby2 in 1930, when they showed that the actual cure of adult squamous cell carcinoma requires from 7 to 10 erythema doses.

When considered in retrospect it now seems odd that the German so-called massive dose or