Therapeutic use of ovarian preparations for relief of the symptoms accompanying the menopause has met with varying and unpredictable success until within the last few years. The production of estrogenic preparations in biologically assayed form was the occasion for substantial improvement in clinical management of these patients. In 1929 the first American report of dependable treatment of the menopause with such material was published.1 Corroborative reports have appeared by Bowman and Bender2 in the field of psychiatry, by Hamblen3 in gynecology and by Werner and Collier4 in internal medicine. Experience with several standardized ovarian preparations is now so widespread among clinicians that there can no longer be the doubt of the efficacy of treatment expressed by King5 in 1928. The usefulness of the estrogenic substance has been shown to extend not only to the commoner types of climacteric symptoms but also to the not infrequent
SEVRINGHAUS EL. THE RELIEF OF MENOPAUSE SYMPTOMS BY ESTROGENIC PREPARATIONS. JAMA. 1935;104(8):624–628. doi:10.1001/jama.1935.02760080020005
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