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Article
February 23, 1935

THE STEROLS OF BLOOD PLASMA

JAMA. 1935;104(8):653-654. doi:10.1001/jama.1935.02760080049014
Abstract

Sterol, it is now generally assumed, is excreted in human feces mainly in the form of coprosterol. This is accompanied by smaller quantities of dihydrocholesterol (beta-cholestanol) and cholesterol.1 In recent years, Schönheimer and his co-workers have confirmed the early observation of Boehm that the dihydrocholesterol is excreted by the wall of the large intestine. The coprosterol of the feces is assumed to be produced by bacterial reduction of cholesterol in the intestine. Furthermore, it has been definitely established that both dihydrocholesterol and coprosterol, when administered orally, are not absorbed from the intestine. Still another sterol, allocholesterol, an isomer of cholesterol, has been considered of importance in sterol metabolism. The significance attached to this compound arises from the fact that the latter yields coprosterol when subjected to catalytic reduction in vitro. Furthermore, allocholesterol has been reported as the only sterol other than cholesterol that produces a significant increase in bile

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