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February 23, 1935


JAMA. 1935;104(8):655. doi:10.1001/jama.1935.02760080051016

The widespread clinical administration of viosterol preparations has raised problems concerning several possible late effects and side actions. Among these questions is that of the formation of gallstones. Since calcium is concerned in their formation, an increase in the calcium content of the bile might predispose to gallstones. This problem is perhaps particularly acute in pregnancy, in which the incidence of gallstones is already high.

Jones and Laing1 have recently undertaken to ascertain whether the current use of viosterol preparations might lead to an increased output of calcium in the bile in dogs. Twenty-five dogs were used in their experiments. The gallbladder was removed and the common duct or cystic duct cannulated and the flow into the cannula brought externally and collected. The dogs were kept on a standard diet with the addition of viosterol. Two concentrations were used: either the viosterol in oil, a preparation containing not less