The pioneer experimental investigations of Edward Mellanby in England on the production of rickets in animals have in large measure given the impetus for the more recent extensive studies of this disorder. Ten years ago he1 announced the successful production of the typical bone defects by means of a diet lacking in "an accessory factor" and thus paved the way for the consideration of rickets as a deficiency disease due to a shortage of some antirachitic factor. Mellanby's experiments2 were performed on puppies. In reviewing the work, Park3 has offered the following criticism: Mellanby's diets were more crude than those of some other investigators; the salt composition of the diets was not taken into consideration; good histologic studies of the bones and chemical examinations of the blood were lacking; the criteria on which chief reliance was placed were not satisfactory. Nevertheless, Park adds, the experiments of Mellanby
THE METABOLISM OF CALCIUM AND PHOSPHORUS IN RICKETS. JAMA. 1928;90(24):1946. doi:10.1001/jama.1928.02690510030012
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