Of the serious disorders of the hematopoietic system, leukemia is most frequently encountered. Although usually associated with splenomegaly or lymphadenopathy, by the presence of which it is readily differentiated, leukemia may be confounded with other conditions characterized by anemia, infection, purpura or lymphadenopathy. The difficulty in diagnosis is due to the many variations that may occur both in the clinical picture and in the laboratory observations.
Leukemia has heretofore been regarded as a disorder characterized by a persistent increase in the number of white blood cells. According to the present conception of the disease, however, an increase in the number of white cells is not an essential diagnostic factor.
The present study comprises observations on 455 patients in Mount Sinai Hospital and in private practice during the past fifteen years, as classified in the accompanying table.
CLASSIFICATION OF MATERIAL
The cases observed were divided into two groups; namely, acute or
ROSENTHAL N, HARRIS W. LEUKEMIA: ITS DIAGNOSIS AND TREATMENT. JAMA. 1935;104(9):702–706. doi:10.1001/jama.1935.02760090006002
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