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March 2, 1935


JAMA. 1935;104(9):710-714. doi:10.1001/jama.1935.02760090014004

The gastro-enterologist is frequently confronted with symptoms, referable to the abdomen, that cannot be explained on the basis of pathologic changes in the gastro-intestinal tract. In a number of cases, exhaustive study and resultant symptomatic management failed to relieve the symptoms. We therefore sought a possible explanation in the urinary tract, in spite of the fact that the urinary symptoms were either lacking or entirely in the background.

Metabolic disturbances associated with the nephritides frequently give rise to symptoms that are purely gastro-intestinal, but these are associated with corresponding blood changes with absorption of the toxic products. This group of cases is not considered in this presentation because the cases are so obviously renal in origin.

With these facts in mind we began to search for a possible explanation of this curious relationship. Reviewing the neurologic aspect, we note the interrelation of the nerve supply of the upper urinary tract,