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Article
March 2, 1935

THE KUPFFER CELLS OF THE LIVER

JAMA. 1935;104(9):745. doi:10.1001/jama.1935.02760090049017
Abstract

Much has been published recently about the reticuloendothelial system, which comprises large phagocytic cells present on the walls of the small blood vessels of many and perhaps all parenchymatous organs. Typical is the Kupffer cell in the vascular channels of the liver. The name refers to the Munich anatomist who first described these cells about 100 years ago. Not only are they intensely phagocytic, ridding the blood of all manner of harmful particles, especially bacteria, but also they are considered by many authorities to have other physiologic powers, notably the ability to form antibodies of various kinds in the development of resistance, and to be the site of normal blood destruction.

The existence and importance of this system of cells, though almost generally accepted, have depended on rather indirect observations. It has been impossible to observe them apart from the neighboring and associated cells, which are present in overwhelming numbers

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