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Comment & Response
November 1, 2016

Association of a Genetic Risk Score With Body Mass Index

Author Affiliations
  • 1School of Criminal Justice, University of Cincinnati, Cincinnati, Ohio
  • 2Department of Sociology, University of North Carolina, Chapel Hill
JAMA. 2016;316(17):1826. doi:10.1001/jama.2016.14945

To the Editor A study by Dr Walter and colleagues1 found differential associations between a polygenic genetic risk score and BMI across different US birth cohorts. In 2015, we published a study about genetic inheritance and body mass.2 One of our analyses was basically identical to theirs in which the following hypothesis was tested: “… that the genetic influence on body mass is greater among recent cohorts than among earlier ones,” using data from the Health and Retirement Study (HRS).

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