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Comment & Response
November 1, 2016

Mechanisms of Ascites Development

Author Affiliations
  • 1University of Arizona College of Medicine, Tucson

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2016;316(17):1828-1829. doi:10.1001/jama.2016.15069

To the Editor Drs Patel and Muir’s JAMA Diagnostic Test Interpretation article1 discussed the evaluation of new-onset ascites, including interpretation of protein and albumin levels in ascitic fluid compared with serum to distinguish among the common causes of ascites—hepatic cirrhosis, heart failure, and peritoneal malignancy. However, their explanation of the underlying pathophysiologic mechanisms in hepatic cirrhosis is not supported by well-substantiated clinical and experimental evidence.2,3

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