The coexistence of nonvenereal ulcerative lesions of the mouth and genitalia was originally reported by Neumann.1 A comprehensive review of this rare condition was recently presented by Wien and Perlstein,2 who collected a total of twenty-nine cases from the literature and reported in addition a personal case, which was the first to be recorded in this country.
There has been considerable variation of opinion regarding the etiology of this condition. One of the theories attributes the ulcerative lesions to an angioneurosis caused by ovarian dysfunction.3 Although the usual coexisting menstrual disorder gives plausibility to this belief, there has been no attempt at a therapeutic test to verify this theory.
This case is reported because the therapeutic result obtained points to a possible endocrine etiology of the disorder and also because of the rarity of the rarity of the condition.
M. M., a woman, aged 23, seen in July 1932, complained
Ziserman AJ. ULCERATIVE VULVITIS AND STOMATITIS OF ENDOCRINE ORIGIN. JAMA. 1935;104(10):826. doi:10.1001/jama.1935.92760100001009
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