[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.168.111.204. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 6, 1931

TREATMENT OF UNDULANT FEVER WITH AN AUTOGENOUS ANTIGEN

Author Affiliations

MOSCOW, IDAHO
From the Department of Bacteriology, University of Idaho, and the Inland Hospital.

JAMA. 1931;96(23):1945-1948. doi:10.1001/jama.1931.02720490025009
Abstract

The present status of our knowledge of the treatment of undulant fever is notably deficient; consequently any method of attack that seems hopeful is worthy of further study. In general, the curative treatment is symptomatic, comparing with the regimen followed in the treatment of typhoid. We are reporting on a method that resulted in the sudden termination of an infection by Brucella suis (Traum) in the hope that it may be tried by others.

A review of the literature shows that antiserums, parasitotrophic chemicals, and vaccines and bacterins, either specific or nonspecific, have been used experimentally with varying degrees of success in the treatment of this disease. The results of the use of antiserums have in general been disappointing. Chemotherapy has been restricted largely to the intravenous injection of dyes. Of these, mercurochrome-220 soluble as used by Gregory and Gage and others,1 and acriflavine hydrochloride as employed by Izar

×