The present status of our knowledge of the treatment of undulant fever is notably deficient; consequently any method of attack that seems hopeful is worthy of further study. In general, the curative treatment is symptomatic, comparing with the regimen followed in the treatment of typhoid. We are reporting on a method that resulted in the sudden termination of an infection by Brucella suis (Traum) in the hope that it may be tried by others.
A review of the literature shows that antiserums, parasitotrophic chemicals, and vaccines and bacterins, either specific or nonspecific, have been used experimentally with varying degrees of success in the treatment of this disease. The results of the use of antiserums have in general been disappointing. Chemotherapy has been restricted largely to the intravenous injection of dyes. Of these, mercurochrome-220 soluble as used by Gregory and Gage and others,1 and acriflavine hydrochloride as employed by Izar
SCHILLING GS, MAGEE CF, LEITCH FM. TREATMENT OF UNDULANT FEVER WITH AN AUTOGENOUS ANTIGEN. JAMA. 1931;96(23):1945–1948. doi:10.1001/jama.1931.02720490025009
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: