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Comment & Response
November 15, 2016

HIV Transmission During Condomless Sex With a Seropositive Partner With Suppressed Infection

Author Affiliations
  • 1Division of Allergy and Infectious Diseases, University of Washington, Seattle
  • 2Division of Pediatric Infectious Disease, University of Washington, Seattle
  • 3Department of Microbiology, University of Washington, Seattle

Copyright 2016 American Medical Association. All Rights Reserved.

JAMA. 2016;316(19):2044-2045. doi:10.1001/jama.2016.16030

To the Editor The PARTNER (Partners of People on ART—A New Evaluation of the Risks) study1 reported no documented cases of human immunodeficiency virus (HIV) transmission during condomless sex from stable sexual partners whose HIV infection was suppressed with antiretroviral therapy (ART). In more than 40 000 condomless sex acts during 1238 couple-years of follow-up, 11 incident HIV infections occurred, but none was linked by phylogenetic analysis to the index partner. Rather, these 11 incident HIV infections were transmitted from outside the sexual partnership. We suggest that a more detailed analysis of HIV transmission linkage is necessary.

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