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November 15, 2016

What to Believe and Do About Statin-Associated Adverse Effects

Author Affiliations
  • 1Hartford Healthcare Heart & Vascular Institute, Hartford Hospital, Hartford, Connecticut
JAMA. 2016;316(19):1969-1970. doi:10.1001/jama.2016.16557

Statins prevent cardiac death and reduce the incidence of acute coronary syndrome, stroke, and venous thromboembolic disease. Patients who take less than 80% of their statin dose have a 45% relative increase in total mortality compared with more adherent patients, an increase greater than that observed with poor adherence to other cardiac drugs including antihypertensive and β-adrenergic blocking agents.1 Yet thousands of patients avoid these life-saving medications because of the presence of or concern about possible statin-associated adverse effects.