In a recent preliminary report on the excretion and fate of bismuth injected in human subjects, we1 stated provisionally that bismuth acted as a diuretic. The considerable increases in urine output occurred in both ambulatory and confined subjects. Since these patients had an uncontrolled fluid intake, it was necessary to test the matter conclusively with patients on a constant fluid intake. This has now been done and our original impression that bismuth acts as a diuretic has been confirmed. Since then we have also tried the oral administration of the bismuth oxysalts, but with nearly equivocal results as to diuresis. This paper reports the important details of the bismuth action after the intramuscular and oral administrations of different compounds.
The following bismuth preparations were injected in single and repeated doses: bismuth metal suspended in dextrose solution, and potassium bismuth tartrate and bismuth salicylate suspended in oil. The
H. G. MEHRTENS, P. J. HANZLIK. BISMUTH AS A DIURETIC. JAMA. 1928;91(4):223–225. doi:10.1001/jama.1928.02700040005003