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April 20, 1935

Current Comment

JAMA. 1935;104(16):1422. doi:10.1001/jama.1935.02760160046017

HORMONES IN THE TREATMENT OF HEMOPHILIA  The limitation of hemophilic manifestations to the male has provided a speculative basis for the theory that some substance peculiar to the female, possibly a hormone, inhibits the appearance of symptoms in girls and women. Some support for this hypothesis was obtained from experiments in which estrogenic substance could not be detected in the urine of hemophilic males whereas small amounts were consistently found in urine from normal males. It seemed possible, therefore, that the estrogenic hormone itself might be involved in producing the immunity of the female sex to this malady, and that the administration of the substance might produce a similar resistance in males afflicted with the disease. Experimental studies of this hypothesis have yielded conflicting results with regard both to the therapeutic efficacy of the estrogenic hormone and to the absence of this substance from the urine of the hemophilic. In

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