In the past six years a number of cases of asthma due to fungi have been reported. Storm van Leeuwen1 described the production of asthma with the dust of grain infected by mites and also experiments in which allergic reactions were produced in guinea-pigs by grain infected with Penicillium glaucum and Aspergillus fumigatus. Cadham2 observed three cases of asthma due to wheat rust (Puccinia graminis) in which inhalation of the rust produced asthma and a vaccine prepared from the rust gave some relief from the asthma. In 1928, Hansen3 reported cases of sensitiveness to several different types of molds. Hopkins, Benham and Kesten4 reported a case of asthma with eczema due to Alternaria. Asthma could be produced in this patient by inhalation of a spray of the filtrate or extract of a culture of Alternaria and also by the intradermal injection of the filtrate. Recently, Bernton
FLOOD CA. OBSERVATIONS ON SENSITIVITY TO DUST FUNGI IN PATIENTS WITH ASTHMA. JAMA. 1931;96(25):2094–2096. doi:10.1001/jama.1931.02720510014004
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