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To the Editor:
—Several articles have recently appeared in which were cited certain long-continued beneficial effects in asthmatic patients resulting from the massage at intervals of the site at which solution of epinephrine hydrochloride, 1: 1,000, had been hypodermically injected. In a recent severe urticaria following the administration of 1,500 units of tetanus antitoxin to the writer, no such benefit could be subjectively or objectively noted following massage of the sites of the injection of 0.5 cc. of solution of epinephrine hydrochloride, 1: 1,000, at the end of two and three hour periods. I was passively immunized with diphtheria antitoxin in 1918. No urticaria followed. June 24, 1928, a deep, crushed, contaminated wound was received. It seemed advisable to administer an immunizing injection of tetanus antitoxin. A preliminary test did not show any signs of sensitization unduly to the horse protein, and the antitoxin was subcutaneously administered. June 29, general
A. G. Gould. EFFECTS OF MASSAGE OF AREA AFTER INJECTION OF EPINEPHRINE. JAMA. 1928;91(6):416–417. doi:10.1001/jama.1928.02700060050031