It has become a platitude that the transformation of protein in the organism is primarily the story of the behavior of amino-acids in the chemical changes involved in intermediary metabolism. When amino-acids reach the blood stream either after absorption from the alimentary tract or as the result of experimental introduction into the circulation, they do not tarry there long. In a short time they find their way into the tissues. Liver and muscle retain a considerable quota for some time. The sequence of events has been described by Halliburton and McDowall1 as follows: Having loaded themselves with amino-acids, the tissues proceed to pick out those they particularly require, either to incorporate them into their own substance or for the production of secretions; those amino-acids not so required, however, may be retained or transferred to some tissue, where they are broken down and the nonamino part used as fuel. There
HEAT PRODUCTION AFTER INGESTION OF PROTEIN. JAMA. 1931;96(25):2106. doi:10.1001/jama.1931.02720510026010
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