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April 27, 1935


Author Affiliations

From the Department of Anatomy, Yale University School of Medicine.

JAMA. 1935;104(17):1498-1502. doi:10.1001/jama.1935.92760170003012

Note.  —This article and the articles in the previous issues of The Journal are part of a series published under the auspices of the Council on Pharmacy and Chemistry. Other articles will appear in succeeding issues. When completed, the series will be published in book from.—Ed.The term "estrus," as used by Heape, designated the restricted period of mating activity of female mammals.1 The outstanding criterion of estrus was the female's intense sex urge or drive. Since sexual activity in women and other female primates is not restricted to such brief intense periods, the term has not been used in connection with the menstrual cycle.Recent experimental work with ovarian hormones has emphasized another aspect of estrus; namely, the rapid growth of the accessory genital organs, which ushers in the estrous period proper. This growth was first induced experimentally by the overian follicular hormone. This hormone is therefore primarily a