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December 12, 1942

Current Comment

JAMA. 1942;120(15):1219. doi:10.1001/jama.1942.02830500049015

LIVER BILE SLEEPS ON  For years "Carter's Little Liver Pills" has been advertised to the public with such claims as the following: "WAKE UP YOUR LIVER BILE—Without Calomel—And You'll Jump Out of Bed in the Morning Rarin' to Go. The liver should pour 2 pints of bile juice into your bowels every day.... It takes those good, old Carter's Little Liver Pills to get these 2 pints of bile flowing freely to make you feel 'up and up.' " Now Ivy, Roback and Stein1 report a series of experiments on dogs with the drugs concerned and they conclude that two pills given intravenously or two, four and six pills intraduodenally "exert no cholecystokinetic and choleretic effect." The authors continue "That is, they do not cause the gallbladder to contract or stimulate the formation of bile by the liver under conditions which permit the gallbladder and the liver to be stimulated

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