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January 2, 1943


Author Affiliations


From the Department of Pediatrics of the Jewish Hospital.

JAMA. 1943;121(1):11-17. doi:10.1001/jama.1943.02840010013003

The literature of the past five years has been rich in papers describing all phases of sulfonamide therapy. The pharmacology of these compounds has been ably reviewed by Marshall1 and by Goodman and Gilman.2 Long and his associates3 have thoroughly described the clinical uses and toxic manifestations. In the pediatric literature, Silverman4 has contributed a critical review of the subject and Bigler and Haralambie5 have published an exhaustive article particularly excellent for its historic and pharmacologic background.

Very few of these papers have been devoted specifically to the chemotherapy of septicemia. The most complete article is that of Herrell and Brown,6 which, however, deals with adult cases. Hamburger and Ruegsegger7 have described 12 cases, and Rammelkamp and Keefer8 have reported 7 cases of staphylococcemia treated with these drugs. Others who have reported small series of cases of staphylococcic septicemia treated with the