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From The JAMA Network
December 20, 2016

Duration of Antibiotic Therapy for Community-Acquired Pneumonia in the Era of Personalized Medicine

Author Affiliations
  • 1Division of General Internal Medicine, Department of Medicine, University of California, San Francisco
  • 2Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • 3Veterans Affairs Pittsburgh Healthcare System, Center for Health Equity Research and Promotion, Pittsburgh, Pennsylvania

Copyright 2016 American Medical Association. All Rights Reserved.

JAMA. 2016;316(23):2544-2545. doi:10.1001/jama.2016.17589

Antibiotic therapy is the cornerstone of management for patients hospitalized with community-acquired pneumonia (CAP), yet the optimal duration of therapy remains unknown. Whereas personalized medicine has gained traction in the treatment of many diseases, adults hospitalized with CAP have traditionally been treated with relatively standard, prolonged antibiotic courses lasting 7 to 14 days. Personalizing the most appropriate treatment duration should balance the risks of illness progression or complications associated with abbreviated treatment durations and those of antibiotic resistance and adverse drug events associated with prolonged antibiotic treatment.