The effect of oil of peppermint on gastric secretion in man and dog is described and balloon tests of gastric motility after oil of peppermint are reported elsewhere.1 Our previous work showed that oil of peppermint diminished gastric acidity. It was important, therefore, in the analysis of the factors concerned in such a diminution of acidity to investigate the effect of the oil of peppermint on the emptying time of the stomach.
Wallace and Jackson2 found that oil of peppermint in the intestine influences gastric secretion by reflex action. Meyer and Gottlieb in their textbook3 state that carminatives increase the muscular activity of the alimentary canal. Muirhead and Gerald4 found that small amounts of volatile oils increase the motility of isolated segments of intestine and that larger doses decrease it. In Cushny's textbook5 it is stated that volatile oils relax the musculature of the stomach
SAPOZNIK HI, ARENS RA, MEYER J, NECHELES H. THE EFFECT OF OIL OF PEPPERMINT ON THE EMPTYING TIME OF THE STOMACH. JAMA. 1935;104(20):1792–1794. doi:10.1001/jama.1935.02760200014003
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