The advent of methods for determining the state of acid-base equilibrium in body fluids has added considerably to our knowledge of such conditions as diabetes and nephritis, in which changes in the acid-base balance may result. From studies on healthy persons as well as on those with acidosis or alkalosis, physiologists may ascribe the neutrality of the blood to a system of acidity regulators or buffers, which, in the case of the blood, consist of mixtures of weak acids and their salts. Governing the acidity or alkalinity of the blood are the ratios of each particular acid to its corresponding salt. It is interesting to note, for instance, that the blood will retain its slight alkalinity to litmus so long as the molecular concentration of carbonic acid is one-twentieth that of the bicarbonate ion. In some instances the blood bicarbonate is depleted (diminished alkali reserve) yet, if the carbon dioxide
ALKALINITY OF THE BLOOD IN RELATION TO THE PROGNOSIS IN CANCER. JAMA. 1931;96(26):2199–2200. doi:10.1001/jama.1931.02720520027012
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