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January 9, 1943

Internal Secretion of the Germinal Tissue of the Testes and Prostatic Hypertrophy

JAMA. 1943;121(2):159. doi:10.1001/jama.1943.02840020067027

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The author discusses the etiology of prostatic hypertrophy as related to the question of (1) more than one hormone formation in the testis, (2) an independent endocrine function of the germinal tissue of the testis, (3) an increased formation of testosterone after cessation of internal secretion in the germinal tissue, (4) isolation and characterization of hormone formed in germinal tissue of the testis and (5) induced changes in the prostate by increased action of testosterone, similar to spontaneous prostatic hypertrophy. Törnblom shows by experimental studies on rats and dogs that two hormones are formed in the testicles, one in the germinal tissue and one in the interstitial cells. The latter hormone (testosterone) stimulates the growth of the prostate and seminal vesicles. The germinal tissue hormone is characterized in relation to testosterone by a greater weight increase of the hypophysis in castrated rats than in the growth of the prostate and

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