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Article
January 16, 1943

INSULIN RESISTANCE DUE TO INFECTION IN DIABETES MELLITUS IN MAN

Author Affiliations

IOWA CITY; MEDICAL CORPS, ARMY OF THE UNITED STATES

From the State University of Iowa College of Medicine.

JAMA. 1943;121(3):173-176. doi:10.1001/jama.1943.02840030011003
Abstract

Infection is probably the most common of the several causes for insulin resistance in diabetes mellitus in man, but the mechanism of this phenomenon is not understood. There are several theories which have been advocated to explain this resistance: (1) decrease of endogenous insulin secretion by the pancreas,1 (2) decrease of effectiveness of endogenous and exogenous insulin,2 (3) increase of metabolic rate,3 (4) greater glycogenolysis by the liver,4 (5) increase of epinephrine secretion by the adrenal,5 (6) decrease of insulin kinase secreted by the liver,6 (7) increase of adrenal cortex secretion,5 (8) increase of secretion by the anterior lobe of the pituitary gland,7 (9) increase of secretion by the thyroid gland,5 (10) decrease in ability of the skeletal muscles to form glycogen8 and (11) increase of inhibitory action on insulin of the blood plasma.9

The present investigation was undertaken

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