Since mercurochrome-220 soluble was first introduced by Young, White and Swartz1 it has come into widespread use in a variety of conditions, and there are numerous reports in the literature on the good results obtained from the application of the aqueous solution. Later, Scott and Hill2 suggested the use of an aqueous-alcohol-acetone solution of mercurochrome for preoperative skin disinfection. They showed that 2 per cent mercurochrome in aqueous-alcohol-acetone solution is at least as effective as tincture of iodine for disinfection of the unbroken skin. Because of the well known disadvantages of tincture of iodine when used for this purpose, the aqueous-alcohol-acetone solution of mercurochrome has been recommended as a substitute for iodine in preparation of the field of operation.
Since the work of Scott and Hill, aqueous-alcohol-acetone solutions of mercurochrome have been used clinically with complete success for preoperative skin disinfection in place of tincture of iodine. It
REDDISH GF, DRAKE WE. MERCUROCHROME-220 SOLUBLE AND U. S. P. TINCTURE OF IODINE: COMPARISON OF GERMICIDAL EFFICIENCY IN SKIN DISINFECTION. JAMA. 1928;91(10):712–716. doi:10.1001/jama.1928.02700100024007
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